Skeletal Muscles

Skeletal Muscles MDCAT MCQs with answers

32 past paper MCQs on Skeletal Muscles, from the Support and Movement unit of MDCAT Biology. The year each question appeared is shown where known; tap “Show answer” for the correct option and a short solution.

Read the notes first Practise the unit as a quiz

1.Which of the following is NOT found in skeletal muscle fibres in humans? (MDCAT 2022)

  1. multiple nuclei
  2. multiple mitochondria
  3. a large amount of myoglobin
  4. a large amount of haemoglobin
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Correct answer: (d) a large amount of haemoglobin

Haemoglobin is in the red blood cells; the muscle's own oxygen store is myoglobin.

2.The cell membrane of a muscle cell is the: (MDCAT 2023)

  1. sarcoplasm
  2. sarcolemma
  3. sarcomere
  4. myofibril
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Correct answer: (b) sarcolemma

Sarcolemma is the name of the plasma membrane of a muscle fibre.

3.The thick filaments in skeletal muscle are composed of: (MDCAT 2024)

  1. actin
  2. myosin
  3. tropomyosin
  4. troponin
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Correct answer: (b) myosin

Myosin makes the thick filament; actin with tropomyosin and troponin makes the thin one.

4.A sarcomere is the part of a myofibril between: (MDCAT 2024)

  1. two I bands
  2. two A bands
  3. two M lines
  4. two Z lines
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Correct answer: (d) two Z lines

The sarcomere, the unit of contraction, runs from one Z line to the next.

5.Myofibrils consist of small contractile units called___ (KMU MDCAT 2025)

  1. Sarcoplasm
  2. Sarcolemma
  3. Sarcomere
  4. Sarcoplasmic reticulum
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Correct answer: (c) Sarcomere

The sarcomere, from one Z line to the next, is the contractile unit of the myofibril.

6.Which part of the sarcomere contain both actin and myosin filament? (KMU MDCAT 2025)

  1. I-band
  2. Z-line
  3. A-band
  4. H-zone
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Correct answer: (c) A-band

The A band is the length of the thick filament, and the thin filaments overlap its ends.

7.H zone of sarcomere consists of: (NUMS MDCAT 2025)

  1. Proteins supporting myosin filaments
  2. Myosin overlapped by actin
  3. Only actin filament
  4. Only myosin filament
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Correct answer: (d) Only myosin filament

The H zone is the middle of the A band, where the thick filaments are not overlapped by thin ones.

8.Skeletal muscle cells are having: (NUMS MDCAT 2025)

  1. Less SER & more RER
  2. More SER & less RER
  3. Equal amount of SER & RER
  4. No SER & RER
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Correct answer: (b) More SER & less RER

The sarcoplasmic reticulum is a specialized smooth endoplasmic reticulum, and a muscle fibre is full of it.

9.Which of the following surrounds myofibril in skeletal muscle that stores and distributes calcium ions during muscle functioning? (SIBA MDCAT 2025)

  1. Sarcolemma
  2. Sarcoplasmic reticulum
  3. Transverse tubules
  4. Sarcoplasm
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Correct answer: (b) Sarcoplasmic reticulum

The sarcoplasmic reticulum wraps each myofibril and holds the calcium the fibre needs.

10.In muscle fibers, T-tubules are extension of the sarcolemma that penetrate into the cell's interior. What is their main function during muscle contraction? (SZABMU MDCAT 2025)

  1. Unblock actin's binding sites.
  2. Conduct nerve impulses deep into the muscle cell.
  3. Synthesize glycogen in the sarcoplasm.
  4. Store calcium ions within the sarcoplasmic reticulum.
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Correct answer: (b) Conduct nerve impulses deep into the muscle cell.

The T tubules carry the action potential from the surface into the depth of the fibre.

11.Thick filaments In skeletal muscles are composed of: (UHS MDCAT 2024)

  1. Actin
  2. Myosin
  3. Tropomyosin
  4. Troponin
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Correct answer: (b) Myosin

The thick filament is myosin; actin makes the thin one.

12.Sarcomere is part of myofibril between: (UHS MDCAT 2024)

  1. Two I bands
  2. Two A bands
  3. Two M lines
  4. Two Z lines
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Correct answer: (d) Two Z lines

A sarcomere runs from one Z line to the next.

13.The ____ surrounds the muscle fibre of the skeletal muscle. (KMU MDCAT 2024)

  1. Cytoplasm
  2. Lacunae
  3. Myofibrils
  4. Sarcoplasm
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Correct answer: (d) Sarcoplasm

The sarcoplasm is the cytoplasm around the myofibrils inside the fibre.

14.Choose the correct for muscle in relaxed position: (NUMS MDCAT 2024)

  1. Exposed binding sites on actin
  2. Broad H-zone in sarcomere
  3. Formation of cross bridges
  4. Ca2+ released in cytosol
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Correct answer: (b) Broad H-zone in sarcomere

At rest the thin filaments are drawn back, so the H zone between them is at its widest.

15.Which of the following is a muscle component that act as store for energy? (UHS MDCAT 2023)

  1. ATP
  2. Creatine-PO4
  3. Myoglobin
  4. Creatinine-PO4
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Correct answer: (b) Creatine-PO4

Creatine phosphate is the quick store that rebuilds ATP in a working muscle.

16.Which of the following is NOT found in skeletal muscle fibers in human? (UHS MDCAT 2023)

  1. Multiple nuclei
  2. Multiple mitochondria
  3. Large amount of myoglobin
  4. Large amount of hemoglobin
Show answer

Correct answer: (d) Large amount of hemoglobin

Muscle stores its oxygen on myoglobin; haemoglobin belongs to the red cells of the blood.

17.What is the function of myoglobin? (SZABMU MDCAT 2023)

  1. Store oxygen
  2. Store CO2
  3. Transport oxygen
  4. Transport CO2
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Correct answer: (a) Store oxygen

Myoglobin holds a reserve of oxygen in the muscle fibre.

18.Sarcoplasmic reticulum of muscle fibers is mainly responsible for: (NUMS MDCAT 2023)

  1. Calcium storage
  2. Protein synthesis
  3. Lipid metabolism
  4. Storing cell wastes
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Correct answer: (a) Calcium storage

The sarcoplasmic reticulum holds the calcium and releases it when the impulse arrives.

19.The cell membrane of muscle cell is: (UHS MDCAT 2023)

  1. Sarcoplasm
  2. Sarcolemma
  3. Sarcomere
  4. Myofibrils
Show answer

Correct answer: (b) Sarcolemma

The membrane of a muscle fibre is the sarcolemma.

20.Which of the following is the separation point between two sarcomere? (PMC MDCAT 2022)

  1. H-zone
  2. A-band
  3. Z-line
  4. M-line
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Correct answer: (c) Z-line

A sarcomere runs from one Z line to the next, so the Z line divides them.

21.Many sarcomere placed end to end and form a: (PMC MDCAT 2022)

  1. Muscle
  2. Fiber
  3. Myofibril
  4. Muscle fiber
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Correct answer: (c) Myofibril

Sarcomeres end to end make a myofibril, and myofibrils fill the muscle fibre.

22.The composition of skeletal muscle is: (PMC MDCAT 2022)

  1. Myosin only
  2. Actin only
  3. Actin, myosin and troponin
  4. Actin, myosin and tropomyosin
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Correct answer: (d) Actin, myosin and tropomyosin

The thin filament is actin with tropomyosin and troponin along it, and the thick one is myosin.

23.Which of the following is the name of the modified endoplasmic reticulum foundin muscle cells? (PMC Practice 2021)

  1. T-tubule
  2. Sarcomere
  3. Myoplasmic reticulum
  4. Sarcoplasmic reticulum
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Correct answer: (d) Sarcoplasmic reticulum

The sarcoplasmic reticulum is the specialized endoplasmic reticulum of a muscle fibre.

24.Many sarcomeres in series make up the length of a: (PMC Practice 2021)

  1. Microtubules
  2. Myofibril
  3. Myosin filament
  4. M-line
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Correct answer: (b) Myofibril

Sarcomeres end to end make up the length of a myofibril.

25.What structure marks the separation between two sarcomeres? (PMC Practice 2021)

  1. I band
  2. H zone
  3. A band
  4. Z line
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Correct answer: (d) Z line

A sarcomere runs from one Z line to the next.

26.What do we call the cell surface membrane of a muscle fibre? (PMC MDCAT 2020)

  1. Sarcolemma
  2. Plasma membrane
  3. Sarcoplasm
  4. Myofibrils
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Correct answer: (a) Sarcolemma

The membrane of a muscle fibre is the sarcolemma.

27.Thin filaments of muscles contain _____ chains of actin molecules. (UHS MDCAT 2019)

  1. Two
  2. One
  3. Three
  4. Four
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Correct answer: (a) Two

The thin filament is two chains of actin monomers twisted round each other.

28.The thick filaments, in a myofibril of muscles, are made of ________. (UHS MDCAT 2019)

  1. Myoglobin
  2. Myosin
  3. Actin
  4. Haemoglobin
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Correct answer: (b) Myosin

The thick filament is myosin.

29.Overlapping of thick and thin filament occur in: (UHS MDCAT 2017)

  1. I band
  2. A band
  3. M band
  4. Z band
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Correct answer: (b) A band

The A band is the length of the thick filament, and the thin ones overlap its ends.

30.Each muscle fibre is surrounded by a modified cell membrance called: (UHS MDCAT 2016)

  1. Sarcolemma
  2. Sarcomere
  3. Myosin Filament
  4. Myofilament
Show answer

Correct answer: (a) Sarcolemma

The membrane of a muscle fibre is the sarcolemma.

31.A sarcomere is the region of a myofibril between two successive: (UHS MDCAT 2015)

  1. M-lines
  2. Z-lines
  3. I-bands
  4. T-tubules
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Correct answer: (b) Z-lines

A sarcomere runs from one Z line to the next.

32.The sarcolemma of muscle fibre folds inwards and forms a system of tubes which runs through the sarcoplasm called: (UHS MDCAT 2015)

  1. Myofilaments
  2. Sarcoplasmic reticulum
  3. Z-lines
  4. Transverse tubules
Show answer

Correct answer: (d) Transverse tubules

The infoldings of the sarcolemma are the transverse, or T, tubules.

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